This gene belongs to the RING finger family, members of which encode proteins characterized by a RING domain, a zinc-binding motif related to the zinc finger domain. The gene product can bind DNA and can act as a transcriptional repressor. It is associated with the multimeric polycomb group protein complex. The gene product interacts with the polycomb group proteins BMI1, EDR1, and CBX4, and colocalizes with these proteins in large nuclear domains. It interacts with the CBX4 protein via its glycine-rich C-terminal domain. The gene maps to the HLA class II region, where it is contiguous with the RING finger genes FABGL and HKE4.[2]
↑Hanson IM, Poustka A, Trowsdale J (Jun 1991). "New genes in the class II region of the human major histocompatibility complex". Genomics. 10 (2): 417–24. doi:10.1016/0888-7543(91)90327-B. PMID1906426.
↑Bárdos JI, Saurin AJ, Tissot C, Duprez E, Freemont PS (Sep 2000). "HPC3 is a new human polycomb orthologue that interacts and associates with RING1 and Bmi1 and has transcriptional repression properties". The Journal of Biological Chemistry. 275 (37): 28785–92. doi:10.1074/jbc.M001835200. PMID10825164.
↑Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID16189514.
Kikuti YY, Tamiya G, Ando A, Chen L, Kimura M, Ferreira E, Tsuji K, Trowsdale J, Inoko H (Jun 1997). "Physical mapping 220 kb centromeric of the human MHC and DNA sequence analysis of the 43-kb segment including the RING1, HKE6, and HKE4 genes". Genomics. 42 (3): 422–35. doi:10.1006/geno.1997.4745. PMID9205114.
Bárdos JI, Saurin AJ, Tissot C, Duprez E, Freemont PS (Sep 2000). "HPC3 is a new human polycomb orthologue that interacts and associates with RING1 and Bmi1 and has transcriptional repression properties". The Journal of Biological Chemistry. 275 (37): 28785–92. doi:10.1074/jbc.M001835200. PMID10825164.
Dahiya A, Wong S, Gonzalo S, Gavin M, Dean DC (Sep 2001). "Linking the Rb and polycomb pathways". Molecular Cell. 8 (3): 557–69. doi:10.1016/S1097-2765(01)00346-X. PMID11583618.
Ogawa H, Ishiguro K, Gaubatz S, Livingston DM, Nakatani Y (May 2002). "A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells". Science. 296 (5570): 1132–6. doi:10.1126/science.1069861. PMID12004135.
Akasaka T, Takahashi N, Suzuki M, Koseki H, Bodmer R, Koga H (Aug 2002). "MBLR, a new RING finger protein resembling mammalian Polycomb gene products, is regulated by cell cycle-dependent phosphorylation". Genes to Cells. 7 (8): 835–50. doi:10.1046/j.1365-2443.2002.00565.x. PMID12167161.
Gil J, Bernard D, Martínez D, Beach D (Jan 2004). "Polycomb CBX7 has a unifying role in cellular lifespan". Nature Cell Biology. 6 (1): 67–72. doi:10.1038/ncb1077. PMID14647293.
Obuse C, Yang H, Nozaki N, Goto S, Okazaki T, Yoda K (Feb 2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase". Genes to Cells. 9 (2): 105–20. doi:10.1111/j.1365-2443.2004.00705.x. PMID15009096.
Wang H, Wang L, Erdjument-Bromage H, Vidal M, Tempst P, Jones RS, Zhang Y (Oct 2004). "Role of histone H2A ubiquitination in Polycomb silencing". Nature. 431 (7010): 873–8. doi:10.1038/nature02985. PMID15386022.
Qin H, Du D, Zhu Y, Li J, Feng L, Liang Y, Han H (Feb 2005). "The PcG protein HPC2 inhibits RBP-J-mediated transcription by interacting with LIM protein KyoT2". FEBS Letters. 579 (5): 1220–6. doi:10.1016/j.febslet.2005.01.022. PMID15710417.
