Thyroid transcription factor 1

Thyroid transcription factor 1
File:PBB Protein TITF1 image.jpg PDB rendering based on 1ftt.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1ftt​
Identifiers
Symbols	TITF1 ; BCH; BHC; NK-2; NKX2.1; NKX2A; TEBP; TTF-1; TTF1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 2488
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE TITF1 210673 x at tn.png
File:PBB GE TITF1 211024 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Thyroid transcription factor 1 (TITF1), also known as NK2 homeobox 1 (NKX2-1), is a human gene.

Further reading

• Lau SK, Luthringer DJ, Eisen RN (2002). "Thyroid transcription factor-1: a review". Appl. Immunohistochem. Mol. Morphol. 10 (2): 97–102. PMID 12051643.CS1 maint: Multiple names: authors list (link)
• Guazzi S, Price M, De Felice M; et al. (1990). "Thyroid nuclear factor 1 (TTF-1) contains a homeodomain and displays a novel DNA binding specificity". EMBO J. 9 (11): 3631–9. PMID 1976511.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Oguchi H, Pan YT, Kimura S (1995). "The complete nucleotide sequence of the mouse thyroid-specific enhancer-binding protein (T/EBP) gene: extensive identity of the deduced amino acid sequence with the human protein". Biochim. Biophys. Acta. 1261 (2): 304–6. PMID 7711079.CS1 maint: Multiple names: authors list (link)
• Saiardi A, Tassi V, De Filippis V, Civitareale D (1995). "Cloning and sequence analysis of human thyroid transcription factor 1". Biochim. Biophys. Acta. 1261 (2): 307–10. PMID 7711080.CS1 maint: Multiple names: authors list (link)
• Ikeda K, Clark JC, Shaw-White JR; et al. (1995). "Gene structure and expression of human thyroid transcription factor-1 in respiratory epithelial cells". J. Biol. Chem. 270 (14): 8108–14. PMID 7713914.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.CS1 maint: Multiple names: authors list (link)
• Ghaffari M, Zeng X, Whitsett JA, Yan C (1998). "Nuclear localization domain of thyroid transcription factor-1 in respiratory epithelial cells". Biochem. J. 328 ( Pt 3): 757–61. PMID 9396717.CS1 maint: Multiple names: authors list (link)
• Hamdan H, Liu H, Li C; et al. (1998). "Structure of the human Nkx2.1 gene". Biochim. Biophys. Acta. 1396 (3): 336–48. PMID 9545595.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Perrone L, Tell G, Di Lauro R (1999). "Calreticulin enhances the transcriptional activity of thyroid transcription factor-1 by binding to its homeodomain". J. Biol. Chem. 274 (8): 4640–5. PMID 9988700.CS1 maint: Multiple names: authors list (link)
• Naltner A, Ghaffari M, Whitsett JA, Yan C (2000). "Retinoic acid stimulation of the human surfactant protein B promoter is thyroid transcription factor 1 site-dependent". J. Biol. Chem. 275 (1): 56–62. PMID 10617585.CS1 maint: Multiple names: authors list (link)
• Missero C, Pirro MT, Di Lauro R (2000). "Multiple ras downstream pathways mediate functional repression of the homeobox gene product TTF-1". Mol. Cell. Biol. 20 (8): 2783–93. PMID 10733581.CS1 maint: Multiple names: authors list (link)
• Naltner A, Wert S, Whitsett JA, Yan C (2000). "Temporal/spatial expression of nuclear receptor coactivators in the mouse lung". Am. J. Physiol. Lung Cell Mol. Physiol. 279 (6): L1066–74. PMID 11076796.CS1 maint: Multiple names: authors list (link)
• Yan C, Naltner A, Conkright J, Ghaffari M (2001). "Protein-protein interaction of retinoic acid receptor alpha and thyroid transcription factor-1 in respiratory epithelial cells". J. Biol. Chem. 276 (24): 21686–91. doi:10.1074/jbc.M011378200. PMID 11274148.CS1 maint: Multiple names: authors list (link)
• Missero C, Pirro MT, Simeone S; et al. (2001). "The DNA glycosylase T:G mismatch-specific thymine DNA glycosylase represses thyroid transcription factor-1-activated transcription". J. Biol. Chem. 276 (36): 33569–75. doi:10.1074/jbc.M104963200. PMID 11438542.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yi M, Tong GX, Murry B, Mendelson CR (2002). "Role of CBP/p300 and SRC-1 in transcriptional regulation of the pulmonary surfactant protein-A (SP-A) gene by thyroid transcription factor-1 (TTF-1)". J. Biol. Chem. 277 (4): 2997–3005. doi:10.1074/jbc.M109793200. PMID 11713256.CS1 maint: Multiple names: authors list (link)
• Liu C, Glasser SW, Wan H, Whitsett JA (2002). "GATA-6 and thyroid transcription factor-1 directly interact and regulate surfactant protein-C gene expression". J. Biol. Chem. 277 (6): 4519–25. doi:10.1074/jbc.M107585200. PMID 11733512.CS1 maint: Multiple names: authors list (link)
• Ng WK, Chow JC, Ng PK (2002). "Thyroid transcription factor-1 is highly sensitive and specific in differentiating metastatic pulmonary from extrapulmonary adenocarcinoma in effusion fluid cytology specimens". Cancer. 96 (1): 43–8. PMID 11836702.CS1 maint: Multiple names: authors list (link)
• Pohlenz J, Dumitrescu A, Zundel D; et al. (2002). "Partial deficiency of thyroid transcription factor 1 produces predominantly neurological defects in humans and mice". J. Clin. Invest. 109 (4): 469–73. PMID 11854318.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Krude H, Schütz B, Biebermann H; et al. (2002). "Choreoathetosis, hypothyroidism, and pulmonary alterations due to human NKX2-1 haploinsufficiency". J. Clin. Invest. 109 (4): 475–80. PMID 11854319.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Miccadei S, De Leo R, Zammarchi E; et al. (2002). "The synergistic activity of thyroid transcription factor 1 and Pax 8 relies on the promoter/enhancer interplay". Mol. Endocrinol. 16 (4): 837–46. PMID 11923479.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• TITF1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.