Retinoic acid receptor gamma: Difference between revisions

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Latest revision as of 05:33, 3 December 2017

Retinoic acid receptor gamma (RAR-γ), also known as NR1B3 (nuclear receptor subfamily 1, group B, member 3) is a nuclear receptor encoded by the RARG gene.^[1]^[2]

Interactions

Retinoic acid receptor gamma has been shown to interact with NCOR1.^[3]

References

↑ "Entrez Gene: RARG retinoic acid receptor, gamma".
↑ Lehmann JM, Hoffmann B, Pfahl M (Feb 1991). "Genomic organization of the retinoic acid receptor gamma gene". Nucleic Acids Research. 19 (3): 573–8. doi:10.1093/nar/19.3.573. PMC 333650. PMID 1849262.
↑ Dowell P, Ishmael JE, Avram D, Peterson VJ, Nevrivy DJ, Leid M (May 1999). "Identification of nuclear receptor corepressor as a peroxisome proliferator-activated receptor alpha interacting protein". The Journal of Biological Chemistry. 274 (22): 15901–7. doi:10.1074/jbc.274.22.15901. PMID 10336495.

Leid M, Kastner P, Lyons R, Nakshatri H, Saunders M, Zacharewski T, Chen JY, Staub A, Garnier JM, Mader S (Jan 1992). "Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently". Cell. 68 (2): 377–95. doi:10.1016/0092-8674(92)90478-U. PMID 1310259.
Vollberg TM, Nervi C, George MD, Fujimoto W, Krust A, Jetten AM (May 1992). "Retinoic acid receptors as regulators of human epidermal keratinocyte differentiation". Molecular Endocrinology. 6 (5): 667–76. doi:10.1210/me.6.5.667. PMID 1318502.
Lehmann JM, Zhang XK, Pfahl M (Jul 1992). "RAR gamma 2 expression is regulated through a retinoic acid response element embedded in Sp1 sites". Molecular and Cellular Biology. 12 (7): 2976–85. doi:10.1128/mcb.12.7.2976. PMC 364511. PMID 1320193.
Mattei MG, Rivière M, Krust A, Ingvarsson S, Vennström B, Islam MQ, Levan G, Kautner P, Zelent A, Chambon P (Aug 1991). "Chromosomal assignment of retinoic acid receptor (RAR) genes in the human, mouse, and rat genomes". Genomics. 10 (4): 1061–9. doi:10.1016/0888-7543(91)90199-O. PMID 1655630.
Kastner P, Krust A, Mendelsohn C, Garnier JM, Zelent A, Leroy P, Staub A, Chambon P (Apr 1990). "Murine isoforms of retinoic acid receptor gamma with specific patterns of expression". Proceedings of the National Academy of Sciences of the United States of America. 87 (7): 2700–4. doi:10.1073/pnas.87.7.2700. PMC 53758. PMID 2157210.
Giguère V, Shago M, Zirngibl R, Tate P, Rossant J, Varmuza S (May 1990). "Identification of a novel isoform of the retinoic acid receptor gamma expressed in the mouse embryo". Molecular and Cellular Biology. 10 (5): 2335–40. doi:10.1128/mcb.10.5.2335. PMC 360581. PMID 2157970.
Ishikawa T, Umesono K, Mangelsdorf DJ, Aburatani H, Stanger BZ, Shibasaki Y, Imawari M, Evans RM, Takaku F (Jun 1990). "A functional retinoic acid receptor encoded by the gene on human chromosome 12". Molecular Endocrinology. 4 (6): 837–44. doi:10.1210/mend-4-6-837. PMID 2172793.
Krust A, Kastner P, Petkovich M, Zelent A, Chambon P (Jul 1989). "A third human retinoic acid receptor, hRAR-gamma". Proceedings of the National Academy of Sciences of the United States of America. 86 (14): 5310–4. doi:10.1073/pnas.86.14.5310. PMC 297611. PMID 2546152.
Renaud JP, Rochel N, Ruff M, Vivat V, Chambon P, Gronemeyer H, Moras D (Dec 1995). "Crystal structure of the RAR-gamma ligand-binding domain bound to all-trans retinoic acid". Nature. 378 (6558): 681–9. doi:10.1038/378681a0. PMID 7501014.
Zhou L, Pang J, Munroe DG, Lau C (May 1993). "A human retinoic acid receptor gamma isoform is homologous to the murine retinoic acid receptor gamma 7". Nucleic Acids Research. 21 (10): 2520. doi:10.1093/nar/21.10.2520. PMC 309563. PMID 7685085.
Zitnik RJ, Kotloff RM, Latifpour J, Zheng T, Whiting NL, Schwalb J, Elias JA (Feb 1994). "Retinoic acid inhibition of IL-1-induced IL-6 production by human lung fibroblasts". Journal of Immunology. 152 (3): 1419–27. PMID 8301142.
Botling J, Castro DS, Oberg F, Nilsson K, Perlmann T (Apr 1997). "Retinoic acid receptor/retinoid X receptor heterodimers can be activated through both subunits providing a basis for synergistic transactivation and cellular differentiation". The Journal of Biological Chemistry. 272 (14): 9443–9. doi:10.1074/jbc.272.14.9443. PMID 9083083.
Lømo J, Smeland EB, Ulven S, Natarajan V, Blomhoff R, Gandhi U, Dawson MI, Blomhoff HK (Apr 1998). "RAR-, not RXR, ligands inhibit cell activation and prevent apoptosis in B-lymphocytes". Journal of Cellular Physiology. 175 (1): 68–77. doi:10.1002/(SICI)1097-4652(199804)175:1<68::AID-JCP8>3.0.CO;2-A. PMID 9491782.
Klaholz BP, Renaud JP, Mitschler A, Zusi C, Chambon P, Gronemeyer H, Moras D (Mar 1998). "Conformational adaptation of agonists to the human nuclear receptor RAR gamma". Nature Structural Biology. 5 (3): 199–202. doi:10.1038/nsb0398-199. PMID 9501913.
Zhang ZP, Gambone CJ, Gabriel JL, Wolfgang CL, Soprano KJ, Soprano DR (Dec 1998). "Arg278, but not Lys229 or Lys236, plays an important role in the binding of retinoic acid by retinoic acid receptor gamma". The Journal of Biological Chemistry. 273 (51): 34016–21. doi:10.1074/jbc.273.51.34016. PMID 9852056.
Yang C, Zhou D, Chen S (Dec 1998). "Modulation of aromatase expression in the breast tissue by ERR alpha-1 orphan receptor". Cancer Research. 58 (24): 5695–700. PMID 9865725.
Nagpal S, Ghosn C, DiSepio D, Molina Y, Sutter M, Klein ES, Chandraratna RA (Aug 1999). "Retinoid-dependent recruitment of a histone H1 displacement activity by retinoic acid receptor". The Journal of Biological Chemistry. 274 (32): 22563–8. doi:10.1074/jbc.274.32.22563. PMID 10428834.
Egea PF, Mitschler A, Rochel N, Ruff M, Chambon P, Moras D (Jun 2000). "Crystal structure of the human RXRalpha ligand-binding domain bound to its natural ligand: 9-cis retinoic acid". The EMBO Journal. 19 (11): 2592–601. doi:10.1093/emboj/19.11.2592. PMC 212755. PMID 10835357.
Boudjelal M, Voorhees JJ, Fisher GJ (Mar 2002). "Retinoid signaling is attenuated by proteasome-mediated degradation of retinoid receptors in human keratinocyte HaCaT cells". Experimental Cell Research. 274 (1): 130–7. doi:10.1006/excr.2001.5450. PMID 11855864.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.

[entrez-1] "Entrez Gene: RARG retinoic acid receptor, gamma".

[pmid1849262-2] Lehmann JM, Hoffmann B, Pfahl M (Feb 1991). "Genomic organization of the retinoic acid receptor gamma gene". Nucleic Acids Research. 19 (3): 573–8. doi:10.1093/nar/19.3.573. PMC 333650. PMID 1849262.

[pmid10336495-3] Dowell P, Ishmael JE, Avram D, Peterson VJ, Nevrivy DJ, Leid M (May 1999). "Identification of nuclear receptor corepressor as a peroxisome proliferator-activated receptor alpha interacting protein". The Journal of Biological Chemistry. 274 (22): 15901–7. doi:10.1074/jbc.274.22.15901. PMID 10336495.

[1]

[2]

[3]

@@ Line 1: / Line 1: @@
- <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox gene}}
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-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+'''Retinoic acid receptor gamma''' ('''RAR-γ'''), also known as '''NR1B3''' (nuclear receptor subfamily 1, group B, member 3) is a [[nuclear receptor]] encoded by the ''RARG'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RARG retinoic acid receptor, gamma| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5916| accessdate = }}</ref><ref name="pmid1849262">{{cite journal | vauthors = Lehmann JM, Hoffmann B, Pfahl M | title = Genomic organization of the retinoic acid receptor gamma gene | journal = Nucleic Acids Research | volume = 19 | issue = 3 | pages = 573–8 | date = Feb 1991 | pmid = 1849262 | pmc = 333650 | doi = 10.1093/nar/19.3.573 }}</ref>
-{{GNF_Protein_box
- | image = PBB_Protein_RARG_image.jpg
- | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1dsz.
- | PDB = {{PDB2|1dsz}}, {{PDB2|1exa}}, {{PDB2|1exx}}, {{PDB2|1fcx}}, {{PDB2|1fcy}}, {{PDB2|1fcz}}, {{PDB2|1fd0}}, {{PDB2|1hra}}, {{PDB2|2lbd}}, {{PDB2|3lbd}}, {{PDB2|4lbd}}
- | Name = Retinoic acid receptor, gamma
- | HGNCid = 9866
- | Symbol = RARG
- | AltSymbols =; NR1B3; RARC
- | OMIM = 180190
- | ECnumber =
- | Homologene = 20263
- | MGIid = 97858
- | Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003707 |text = steroid hormone receptor activity}} {{GNF_GO|id=GO:0003708 |text = retinoic acid receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
- | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005667 |text = transcription factor complex}}
- | Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0043065 |text = positive regulation of apoptosis}} {{GNF_GO|id=GO:0045944 |text = positive regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0048048 |text = embryonic eye morphogenesis}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 5916
-    | Hs_Ensembl =
-    | Hs_RefseqProtein = XP_945931
-    | Hs_RefseqmRNA = XM_940838
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr =
-    | Hs_GenLoc_start =
-    | Hs_GenLoc_end =
-    | Hs_Uniprot =
-    | Mm_EntrezGene = 19411
-    | Mm_Ensembl = ENSMUSG00000001288
-    | Mm_RefseqmRNA = NM_001042727
-    | Mm_RefseqProtein = NP_001036192
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 15
-    | Mm_GenLoc_start = 102062974
-    | Mm_GenLoc_end = 102085313
-    | Mm_Uniprot = Q3UG86
-  }}
-}}
-'''Retinoic acid receptor gamma''' ('''RAR-gamma'''), also known as '''NR1B3''' (nuclear receptor subfamily 1, group B, member 3) is a [[nuclear receptor]] encoded by the {{gene|RARG}} gene.<ref name="entrez">{{cite web | title = Entrez Gene: RARG retinoic acid receptor, gamma| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5916| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+== Interactions ==
-{{PBB_Summary
-| section_title =
-| summary_text =
-}}
-==See also==
+Retinoic acid receptor gamma has been shown to [[Protein-protein_interaction|interact]] with [[nuclear receptor co-repressor 1|NCOR1]].<ref name="pmid10336495">{{cite journal | vauthors = Dowell P, Ishmael JE, Avram D, Peterson VJ, Nevrivy DJ, Leid M | title = Identification of nuclear receptor corepressor as a peroxisome proliferator-activated receptor alpha interacting protein | journal = The Journal of Biological Chemistry | volume = 274 | issue = 22 | pages = 15901–7 | date = May 1999 | pmid = 10336495 | doi = 10.1074/jbc.274.22.15901 }}</ref>
+== See also ==
 * [[Retinoic acid receptor]]
-==References==
+== References ==
-{{reflist|2}}
+{{reflist}}
-==Further reading==
+== Further reading ==
 {{refbegin | 2}}
-{{PBB_Further_reading
+* {{cite journal | vauthors = Leid M, Kastner P, Lyons R, Nakshatri H, Saunders M, Zacharewski T, Chen JY, Staub A, Garnier JM, Mader S | title = Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently | journal = Cell | volume = 68 | issue = 2 | pages = 377–95 | date = Jan 1992 | pmid = 1310259 | doi = 10.1016/0092-8674(92)90478-U }}
-| citations =
+* {{cite journal | vauthors = Vollberg TM, Nervi C, George MD, Fujimoto W, Krust A, Jetten AM | title = Retinoic acid receptors as regulators of human epidermal keratinocyte differentiation | journal = Molecular Endocrinology | volume = 6 | issue = 5 | pages = 667–76 | date = May 1992 | pmid = 1318502 | doi = 10.1210/me.6.5.667 }}
-*{{cite journal  | author=Leid M, Kastner P, Lyons R, ''et al.'' |title=Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently. |journal=Cell |volume=68 |issue= 2 |pages= 377-95 |year= 1992 |pmid= 1310259 |doi=  }}
+* {{cite journal | vauthors = Lehmann JM, Zhang XK, Pfahl M | title = RAR gamma 2 expression is regulated through a retinoic acid response element embedded in Sp1 sites | journal = Molecular and Cellular Biology | volume = 12 | issue = 7 | pages = 2976–85 | date = Jul 1992 | pmid = 1320193 | pmc = 364511 | doi =  10.1128/mcb.12.7.2976}}
-*{{cite journal  | author=Vollberg TM, Nervi C, George MD, ''et al.'' |title=Retinoic acid receptors as regulators of human epidermal keratinocyte differentiation. |journal=Mol. Endocrinol. |volume=6 |issue= 5 |pages= 667-76 |year= 1992 |pmid= 1318502 |doi=  }}
+* {{cite journal | vauthors = Mattei MG, Rivière M, Krust A, Ingvarsson S, Vennström B, Islam MQ, Levan G, Kautner P, Zelent A, Chambon P | title = Chromosomal assignment of retinoic acid receptor (RAR) genes in the human, mouse, and rat genomes | journal = Genomics | volume = 10 | issue = 4 | pages = 1061–9 | date = Aug 1991 | pmid = 1655630 | doi = 10.1016/0888-7543(91)90199-O }}
-*{{cite journal  | author=Lehmann JM, Zhang XK, Pfahl M |title=RAR gamma 2 expression is regulated through a retinoic acid response element embedded in Sp1 sites. |journal=Mol. Cell. Biol. |volume=12 |issue= 7 |pages= 2976-85 |year= 1992 |pmid= 1320193 |doi=  }}
+* {{cite journal | vauthors = Kastner P, Krust A, Mendelsohn C, Garnier JM, Zelent A, Leroy P, Staub A, Chambon P | title = Murine isoforms of retinoic acid receptor gamma with specific patterns of expression | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 87 | issue = 7 | pages = 2700–4 | date = Apr 1990 | pmid = 2157210 | pmc = 53758 | doi = 10.1073/pnas.87.7.2700 }}
-*{{cite journal  | author=Mattei MG, Rivière M, Krust A, ''et al.'' |title=Chromosomal assignment of retinoic acid receptor (RAR) genes in the human, mouse, and rat genomes. |journal=Genomics |volume=10 |issue= 4 |pages= 1061-9 |year= 1991 |pmid= 1655630 |doi=  }}
+* {{cite journal | vauthors = Giguère V, Shago M, Zirngibl R, Tate P, Rossant J, Varmuza S | title = Identification of a novel isoform of the retinoic acid receptor gamma expressed in the mouse embryo | journal = Molecular and Cellular Biology | volume = 10 | issue = 5 | pages = 2335–40 | date = May 1990 | pmid = 2157970 | pmc = 360581 | doi =  10.1128/mcb.10.5.2335}}
-*{{cite journal  | author=Lehmann JM, Hoffmann B, Pfahl M |title=Genomic organization of the retinoic acid receptor gamma gene. |journal=Nucleic Acids Res. |volume=19 |issue= 3 |pages= 573-8 |year= 1991 |pmid= 1849262 |doi=  }}
+* {{cite journal | vauthors = Ishikawa T, Umesono K, Mangelsdorf DJ, Aburatani H, Stanger BZ, Shibasaki Y, Imawari M, Evans RM, Takaku F | title = A functional retinoic acid receptor encoded by the gene on human chromosome 12 | journal = Molecular Endocrinology | volume = 4 | issue = 6 | pages = 837–44 | date = Jun 1990 | pmid = 2172793 | doi = 10.1210/mend-4-6-837 }}
-*{{cite journal  | author=Kastner P, Krust A, Mendelsohn C, ''et al.'' |title=Murine isoforms of retinoic acid receptor gamma with specific patterns of expression. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 7 |pages= 2700-4 |year= 1990 |pmid= 2157210 |doi=  }}
+* {{cite journal | vauthors = Krust A, Kastner P, Petkovich M, Zelent A, Chambon P | title = A third human retinoic acid receptor, hRAR-gamma | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 86 | issue = 14 | pages = 5310–4 | date = Jul 1989 | pmid = 2546152 | pmc = 297611 | doi = 10.1073/pnas.86.14.5310 }}
-*{{cite journal  | author=Giguère V, Shago M, Zirngibl R, ''et al.'' |title=Identification of a novel isoform of the retinoic acid receptor gamma expressed in the mouse embryo. |journal=Mol. Cell. Biol. |volume=10 |issue= 5 |pages= 2335-40 |year= 1990 |pmid= 2157970 |doi=  }}
+* {{cite journal | vauthors = Renaud JP, Rochel N, Ruff M, Vivat V, Chambon P, Gronemeyer H, Moras D | title = Crystal structure of the RAR-gamma ligand-binding domain bound to all-trans retinoic acid | journal = Nature | volume = 378 | issue = 6558 | pages = 681–9 | date = Dec 1995 | pmid = 7501014 | doi = 10.1038/378681a0 }}
-*{{cite journal  | author=Ishikawa T, Umesono K, Mangelsdorf DJ, ''et al.'' |title=A functional retinoic acid receptor encoded by the gene on human chromosome 12. |journal=Mol. Endocrinol. |volume=4 |issue= 6 |pages= 837-44 |year= 1990 |pmid= 2172793 |doi=  }}
+* {{cite journal | vauthors = Zhou L, Pang J, Munroe DG, Lau C | title = A human retinoic acid receptor gamma isoform is homologous to the murine retinoic acid receptor gamma 7 | journal = Nucleic Acids Research | volume = 21 | issue = 10 | pages = 2520 | date = May 1993 | pmid = 7685085 | pmc = 309563 | doi = 10.1093/nar/21.10.2520 }}
-*{{cite journal  | author=Krust A, Kastner P, Petkovich M, ''et al.'' |title=A third human retinoic acid receptor, hRAR-gamma. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 14 |pages= 5310-4 |year= 1989 |pmid= 2546152 |doi=  }}
+* {{cite journal | vauthors = Zitnik RJ, Kotloff RM, Latifpour J, Zheng T, Whiting NL, Schwalb J, Elias JA | title = Retinoic acid inhibition of IL-1-induced IL-6 production by human lung fibroblasts | journal = Journal of Immunology | volume = 152 | issue = 3 | pages = 1419–27 | date = Feb 1994 | pmid = 8301142 | doi =  }}
-*{{cite journal  | author=Renaud JP, Rochel N, Ruff M, ''et al.'' |title=Crystal structure of the RAR-gamma ligand-binding domain bound to all-trans retinoic acid. |journal=Nature |volume=378 |issue= 6558 |pages= 681-9 |year= 1996 |pmid= 7501014 |doi= 10.1038/378681a0 }}
+* {{cite journal | vauthors = Botling J, Castro DS, Oberg F, Nilsson K, Perlmann T | title = Retinoic acid receptor/retinoid X receptor heterodimers can be activated through both subunits providing a basis for synergistic transactivation and cellular differentiation | journal = The Journal of Biological Chemistry | volume = 272 | issue = 14 | pages = 9443–9 | date = Apr 1997 | pmid = 9083083 | doi = 10.1074/jbc.272.14.9443 }}
-*{{cite journal  | author=Zhou L, Pang J, Munroe DG, Lau C |title=A human retinoic acid receptor gamma isoform is homologous to the murine retinoic acid receptor gamma 7. |journal=Nucleic Acids Res. |volume=21 |issue= 10 |pages= 2520 |year= 1993 |pmid= 7685085 |doi=  }}
+* {{cite journal | vauthors = Lømo J, Smeland EB, Ulven S, Natarajan V, Blomhoff R, Gandhi U, Dawson MI, Blomhoff HK | title = RAR-, not RXR, ligands inhibit cell activation and prevent apoptosis in B-lymphocytes | journal = Journal of Cellular Physiology | volume = 175 | issue = 1 | pages = 68–77 | date = Apr 1998 | pmid = 9491782 | doi = 10.1002/(SICI)1097-4652(199804)175:1<68::AID-JCP8>3.0.CO;2-A }}
-*{{cite journal  | author=Zitnik RJ, Kotloff RM, Latifpour J, ''et al.'' |title=Retinoic acid inhibition of IL-1-induced IL-6 production by human lung fibroblasts. |journal=J. Immunol. |volume=152 |issue= 3 |pages= 1419-27 |year= 1994 |pmid= 8301142 |doi=  }}
+* {{cite journal | vauthors = Klaholz BP, Renaud JP, Mitschler A, Zusi C, Chambon P, Gronemeyer H, Moras D | title = Conformational adaptation of agonists to the human nuclear receptor RAR gamma | journal = Nature Structural Biology | volume = 5 | issue = 3 | pages = 199–202 | date = Mar 1998 | pmid = 9501913 | doi = 10.1038/nsb0398-199 }}
-*{{cite journal  | author=Botling J, Castro DS, Oberg F, ''et al.'' |title=Retinoic acid receptor/retinoid X receptor heterodimers can be activated through both subunits providing a basis for synergistic transactivation and cellular differentiation. |journal=J. Biol. Chem. |volume=272 |issue= 14 |pages= 9443-9 |year= 1997 |pmid= 9083083 |doi=  }}
+* {{cite journal | vauthors = Zhang ZP, Gambone CJ, Gabriel JL, Wolfgang CL, Soprano KJ, Soprano DR | title = Arg278, but not Lys229 or Lys236, plays an important role in the binding of retinoic acid by retinoic acid receptor gamma | journal = The Journal of Biological Chemistry | volume = 273 | issue = 51 | pages = 34016–21 | date = Dec 1998 | pmid = 9852056 | doi = 10.1074/jbc.273.51.34016 }}
-*{{cite journal  | author=Lømo J, Smeland EB, Ulven S, ''et al.'' |title=RAR-, not RXR, ligands inhibit cell activation and prevent apoptosis in B-lymphocytes. |journal=J. Cell. Physiol. |volume=175 |issue= 1 |pages= 68-77 |year= 1998 |pmid= 9491782 |doi= 10.1002/(SICI)1097-4652(199804)175:1<68::AID-JCP8>3.0.CO;2-A }}
+* {{cite journal | vauthors = Yang C, Zhou D, Chen S | title = Modulation of aromatase expression in the breast tissue by ERR alpha-1 orphan receptor | journal = Cancer Research | volume = 58 | issue = 24 | pages = 5695–700 | date = Dec 1998 | pmid = 9865725 | doi =  }}
-*{{cite journal  | author=Klaholz BP, Renaud JP, Mitschler A, ''et al.'' |title=Conformational adaptation of agonists to the human nuclear receptor RAR gamma. |journal=Nat. Struct. Biol. |volume=5 |issue= 3 |pages= 199-202 |year= 1998 |pmid= 9501913 |doi=  }}
+* {{cite journal | vauthors = Nagpal S, Ghosn C, DiSepio D, Molina Y, Sutter M, Klein ES, Chandraratna RA | title = Retinoid-dependent recruitment of a histone H1 displacement activity by retinoic acid receptor | journal = The Journal of Biological Chemistry | volume = 274 | issue = 32 | pages = 22563–8 | date = Aug 1999 | pmid = 10428834 | doi = 10.1074/jbc.274.32.22563 }}
-*{{cite journal  | author=Zhang ZP, Gambone CJ, Gabriel JL, ''et al.'' |title=Arg278, but not Lys229 or Lys236, plays an important role in the binding of retinoic acid by retinoic acid receptor gamma. |journal=J. Biol. Chem. |volume=273 |issue= 51 |pages= 34016-21 |year= 1999 |pmid= 9852056 |doi=  }}
+* {{cite journal | vauthors = Egea PF, Mitschler A, Rochel N, Ruff M, Chambon P, Moras D | title = Crystal structure of the human RXRalpha ligand-binding domain bound to its natural ligand: 9-cis retinoic acid | journal = The EMBO Journal | volume = 19 | issue = 11 | pages = 2592–601 | date = Jun 2000 | pmid = 10835357 | pmc = 212755 | doi = 10.1093/emboj/19.11.2592 }}
-*{{cite journal  | author=Yang C, Zhou D, Chen S |title=Modulation of aromatase expression in the breast tissue by ERR alpha-1 orphan receptor. |journal=Cancer Res. |volume=58 |issue= 24 |pages= 5695-700 |year= 1999 |pmid= 9865725 |doi=  }}
+* {{cite journal | vauthors = Boudjelal M, Voorhees JJ, Fisher GJ | title = Retinoid signaling is attenuated by proteasome-mediated degradation of retinoid receptors in human keratinocyte HaCaT cells | journal = Experimental Cell Research | volume = 274 | issue = 1 | pages = 130–7 | date = Mar 2002 | pmid = 11855864 | doi = 10.1006/excr.2001.5450 }}
-*{{cite journal  | author=Nagpal S, Ghosn C, DiSepio D, ''et al.'' |title=Retinoid-dependent recruitment of a histone H1 displacement activity by retinoic acid receptor. |journal=J. Biol. Chem. |volume=274 |issue= 32 |pages= 22563-8 |year= 1999 |pmid= 10428834 |doi=  }}
-*{{cite journal  | author=Egea PF, Mitschler A, Rochel N, ''et al.'' |title=Crystal structure of the human RXRalpha ligand-binding domain bound to its natural ligand: 9-cis retinoic acid. |journal=EMBO J. |volume=19 |issue= 11 |pages= 2592-601 |year= 2000 |pmid= 10835357 |doi= 10.1093/emboj/19.11.2592 }}
-*{{cite journal  | author=Boudjelal M, Voorhees JJ, Fisher GJ |title=Retinoid signaling is attenuated by proteasome-mediated degradation of retinoid receptors in human keratinocyte HaCaT cells. |journal=Exp. Cell Res. |volume=274 |issue= 1 |pages= 130-7 |year= 2002 |pmid= 11855864 |doi= 10.1006/excr.2001.5450 }}
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+{{gene-12-stub}}
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+{{PDB Gallery|geneid=5916}}
+{{Transcription factors|g2}}
+{{Retinoid receptor modulators}}
 [[Category:Intracellular receptors]]
 [[Category:Transcription factors]]

v t e Retinoid receptor modulators
RAR	Agonists: 9CDHRA 9-cis-Retinoic acid (alitretinoin) AC-261066 AC-55649 Acitretin Adapalene all-trans-Retinoic acid (tretinoin) AM-580 BMS-493 BMS-753 BMS-961 CD-1530 CD-2314 CD-437 Ch-55 EC 23 Etretinate Fenretinide Isotretinoin Palovarotene Retinoic acid Retinol (vitamin A) Tamibarotene Tazarotene Tazarotenic acid TTNPB Antagonists: BMS-195614 BMS-493 CD-2665 ER-50891 LE-135 MM-11253 Retinoic acid metabolism inhibitors: Liarozole
RXR	Agonists: 9CDHRA 9-cis-Retinoic acid (alitretinoin) all-trans-Retinoic acid (tretinoin) Bexarotene CD 3254 Docosahexaenoic acid Fluorobexarotene Isotretinoin LG-100268 LG-101506 LG-100754 Retinoic acid Retinol (vitamin A) SR-11237 Antagonists: HX-531 HX-630 LG-100754 PA-452 UVI-3003 HX-603 LE135 (RAR beta selective) LE-540 CD3254 PA-451 PA-452 Rhein HX-711 6-(N-ethyl-N-(5-isobutoxy-4-isopropyl-2-(E)-styrylphenyl)amino)nicotinic acid
See also Receptor/signaling modulators Nuclear receptor modulators

Retinoic acid receptor gamma: Difference between revisions

Latest revision as of 05:33, 3 December 2017

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