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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Transcriptional regulator Kaiso''' is a [[protein]] that in humans is encoded by the ''ZBTB33'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ZBTB33 zinc finger and BTB domain containing 33| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10009| accessdate = }}</ref> This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-α2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear import of this protein. Alternatively spliced transcript variants encoding the same protein have been identified.<ref>{{Cite web|url=https://www.ncbi.nlm.nih.gov/gene/10009|title=ZBTB33 zinc finger and BTB domain containing 33 [Homo sapiens (human)] - Gene - NCBI|website=www.ncbi.nlm.nih.gov|access-date=2016-03-22}}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = Zinc finger and BTB domain containing 33
| HGNCid = 16682
| Symbol = ZBTB33
| AltSymbols =; ZNF-kaiso; ZNF348
| OMIM = 300329
| ECnumber = 
| Homologene = 4931
| MGIid = 1927290
| GeneAtlas_image1 = PBB_GE_ZBTB33_214631_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0016055 |text = Wnt receptor signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10009
    | Hs_Ensembl = ENSG00000177485
    | Hs_RefseqProtein = NP_006768
    | Hs_RefseqmRNA = NM_006777
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = X
    | Hs_GenLoc_start = 119268635
    | Hs_GenLoc_end = 119276279
    | Hs_Uniprot = Q86T24
    | Mm_EntrezGene = 56805
    | Mm_Ensembl = ENSMUSG00000048047
    | Mm_RefseqmRNA = NM_001079513
    | Mm_RefseqProtein = NP_001072981
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = X
    | Mm_GenLoc_start = 34434468
    | Mm_GenLoc_end = 34439167
    | Mm_Uniprot = A0PJC8
  }}
}}
'''Zinc finger and BTB domain containing 33''', also known as '''ZBTB33''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ZBTB33 zinc finger and BTB domain containing 33| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10009| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
ZBTB33 has been shown to [[Protein-protein interaction|interact]] with [[HDAC3]],<ref name=pmid14527417>{{cite journal | vauthors = Yoon HG, Chan DW, Reynolds AB, Qin J, Wong J | title = N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso | journal = Molecular Cell | volume = 12 | issue = 3 | pages = 723–34 | date = Sep 2003 | pmid = 14527417 | doi = 10.1016/j.molcel.2003.08.008 }}</ref> [[Nuclear receptor co-repressor 1]]<ref name=pmid14527417/> and [[CTNND1]].<ref name=pmid10207085>{{cite journal | vauthors = Daniel JM, Reynolds AB | title = The catenin p120(ctn) interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor | journal = Molecular and Cellular Biology | volume = 19 | issue = 5 | pages = 3614–23 | date = May 1999 | pmid = 10207085 | pmc = 84161 | doi=10.1128/mcb.19.5.3614}}</ref>
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Daniel JM, Reynolds AB | title = The catenin p120(ctn) interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor | journal = Molecular and Cellular Biology | volume = 19 | issue = 5 | pages = 3614–23 | date = May 1999 | pmid = 10207085 | pmc = 84161 | doi =  10.1128/mcb.19.5.3614}}
| citations =
* {{cite journal | vauthors = Hartley JL, Temple GF, Brasch MA | title = DNA cloning using in vitro site-specific recombination | journal = Genome Research | volume = 10 | issue = 11 | pages = 1788–95 | date = Nov 2000 | pmid = 11076863 | pmc = 310948 | doi = 10.1101/gr.143000 }}
*{{cite journal | author=Daniel JM, Reynolds AB |title=The catenin p120(ctn) interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor. |journal=Mol. Cell. Biol. |volume=19 |issue= 5 |pages= 3614-23 |year= 1999 |pmid= 10207085 |doi=  }}
* {{cite journal | vauthors = Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A | title = Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs | journal = Genome Research | volume = 11 | issue = 3 | pages = 422–35 | date = Mar 2001 | pmid = 11230166 | pmc = 311072 | doi = 10.1101/gr.GR1547R }}
*{{cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi= }}
* {{cite journal | vauthors = Prokhortchouk A, Hendrich B, Jørgensen H, Ruzov A, Wilm M, Georgiev G, Bird A, Prokhortchouk E | title = The p120 catenin partner Kaiso is a DNA methylation-dependent transcriptional repressor | journal = Genes & Development | volume = 15 | issue = 13 | pages = 1613–8 | date = Jul 2001 | pmid = 11445535 | pmc = 312733 | doi = 10.1101/gad.198501 }}
*{{cite journal | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
* {{cite journal | vauthors = Daniel JM, Ireton RC, Reynolds AB | title = Monoclonal antibodies to Kaiso: a novel transcription factor and p120ctn-binding protein | journal = Hybridoma | volume = 20 | issue = 3 | pages = 159–66 | date = Jun 2001 | pmid = 11461664 | doi = 10.1089/027245701750293484 }}
*{{cite journal | author=Prokhortchouk A, Hendrich B, Jørgensen H, ''et al.'' |title=The p120 catenin partner Kaiso is a DNA methylation-dependent transcriptional repressor. |journal=Genes Dev. |volume=15 |issue= 13 |pages= 1613-8 |year= 2001 |pmid= 11445535 |doi= 10.1101/gad.198501 }}
* {{cite journal | vauthors = Yoon HG, Chan DW, Reynolds AB, Qin J, Wong J | title = N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso | journal = Molecular Cell | volume = 12 | issue = 3 | pages = 723–34 | date = Sep 2003 | pmid = 14527417 | doi = 10.1016/j.molcel.2003.08.008 }}
*{{cite journal | author=Daniel JM, Ireton RC, Reynolds AB |title=Monoclonal antibodies to Kaiso: a novel transcription factor and p120ctn-binding protein. |journal=Hybridoma |volume=20 |issue= 3 |pages= 159-66 |year= 2001 |pmid= 11461664 |doi= 10.1089/027245701750293484 }}
* {{cite journal | vauthors = Kondapalli J, Flozak AS, Albuquerque ML | title = Laminar shear stress differentially modulates gene expression of p120 catenin, Kaiso transcription factor, and vascular endothelial cadherin in human coronary artery endothelial cells | journal = The Journal of Biological Chemistry | volume = 279 | issue = 12 | pages = 11417–24 | date = Mar 2004 | pmid = 14699141 | doi = 10.1074/jbc.M306057200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A | title = From ORFeome to biology: a functional genomics pipeline | journal = Genome Research | volume = 14 | issue = 10B | pages = 2136–44 | date = Oct 2004 | pmid = 15489336 | pmc = 528930 | doi = 10.1101/gr.2576704 }}
*{{cite journal  | author=Yoon HG, Chan DW, Reynolds AB, ''et al.'' |title=N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso. |journal=Mol. Cell |volume=12 |issue= 3 |pages= 723-34 |year= 2003 |pmid= 14527417 |doi= }}
* {{cite journal | vauthors = Kim SW, Park JI, Spring CM, Sater AK, Ji H, Otchere AA, Daniel JM, McCrea PD | title = Non-canonical Wnt signals are modulated by the Kaiso transcriptional repressor and p120-catenin | journal = Nature Cell Biology | volume = 6 | issue = 12 | pages = 1212–20 | date = Dec 2004 | pmid = 15543138 | doi = 10.1038/ncb1191 }}
*{{cite journal | author=Kondapalli J, Flozak AS, Albuquerque ML |title=Laminar shear stress differentially modulates gene expression of p120 catenin, Kaiso transcription factor, and vascular endothelial cadherin in human coronary artery endothelial cells. |journal=J. Biol. Chem. |volume=279 |issue= 12 |pages= 11417-24 |year= 2004 |pmid= 14699141 |doi= 10.1074/jbc.M306057200 }}
* {{cite journal | vauthors = Ruzov A, Dunican DS, Prokhortchouk A, Pennings S, Stancheva I, Prokhortchouk E, Meehan RR | title = Kaiso is a genome-wide repressor of transcription that is essential for amphibian development | journal = Development | volume = 131 | issue = 24 | pages = 6185–94 | date = Dec 2004 | pmid = 15548582 | doi = 10.1242/dev.01549 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
* {{cite journal | vauthors = Kelly KF, Otchere AA, Graham M, Daniel JM | title = Nuclear import of the BTB/POZ transcriptional regulator Kaiso | journal = Journal of Cell Science | volume = 117 | issue = Pt 25 | pages = 6143–52 | date = Dec 2004 | pmid = 15564377 | doi = 10.1242/jcs.01541 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
* {{cite journal | vauthors = Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ | title = Immunoaffinity profiling of tyrosine phosphorylation in cancer cells | journal = Nature Biotechnology | volume = 23 | issue = 1 | pages = 94–101 | date = Jan 2005 | pmid = 15592455 | doi = 10.1038/nbt1046 }}
*{{cite journal  | author=Wiemann S, Arlt D, Huber W, ''et al.'' |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136-44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 }}
* {{cite journal | vauthors = Soubry A, van Hengel J, Parthoens E, Colpaert C, Van Marck E, Waltregny D, Reynolds AB, van Roy F | title = Expression and nuclear location of the transcriptional repressor Kaiso is regulated by the tumor microenvironment | journal = Cancer Research | volume = 65 | issue = 6 | pages = 2224–33 | date = Mar 2005 | pmid = 15781635 | doi = 10.1158/0008-5472.CAN-04-2020 }}
*{{cite journal | author=Kim SW, Park JI, Spring CM, ''et al.'' |title=Non-canonical Wnt signals are modulated by the Kaiso transcriptional repressor and p120-catenin. |journal=Nat. Cell Biol. |volume=6 |issue= 12 |pages= 1212-20 |year= 2005 |pmid= 15543138 |doi= 10.1038/ncb1191 }}
* {{cite journal | vauthors = Spring CM, Kelly KF, O'Kelly I, Graham M, Crawford HC, Daniel JM | title = The catenin p120ctn inhibits Kaiso-mediated transcriptional repression of the beta-catenin/TCF target gene matrilysin | journal = Experimental Cell Research | volume = 305 | issue = 2 | pages = 253–65 | date = May 2005 | pmid = 15817151 | doi = 10.1016/j.yexcr.2005.01.007 }}
*{{cite journal | author=Ruzov A, Dunican DS, Prokhortchouk A, ''et al.'' |title=Kaiso is a genome-wide repressor of transcription that is essential for amphibian development. |journal=Development |volume=131 |issue= 24 |pages= 6185-94 |year= 2005 |pmid= 15548582 |doi= 10.1242/dev.01549 }}
* {{cite journal | vauthors = Arányi T, Faucheux BA, Khalfallah O, Vodjdani G, Biguet NF, Mallet J, Meloni R | title = The tissue-specific methylation of the human tyrosine hydroxylase gene reveals new regulatory elements in the first exon | journal = Journal of Neurochemistry | volume = 94 | issue = 1 | pages = 129–39 | date = Jul 2005 | pmid = 15953356 | doi = 10.1111/j.1471-4159.2005.03173.x }}
*{{cite journal | author=Kelly KF, Otchere AA, Graham M, Daniel JM |title=Nuclear import of the BTB/POZ transcriptional regulator Kaiso. |journal=J. Cell. Sci. |volume=117 |issue= Pt 25 |pages= 6143-52 |year= 2005 |pmid= 15564377 |doi= 10.1242/jcs.01541 }}
* {{cite journal | vauthors = Defossez PA, Kelly KF, Filion GJ, Pérez-Torrado R, Magdinier F, Menoni H, Nordgaard CL, Daniel JM, Gilson E | title = The human enhancer blocker CTC-binding factor interacts with the transcription factor Kaiso | journal = The Journal of Biological Chemistry | volume = 280 | issue = 52 | pages = 43017–23 | date = Dec 2005 | pmid = 16230345 | doi = 10.1074/jbc.M510802200 }}
*{{cite journal | author=Rush J, Moritz A, Lee KA, ''et al.'' |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94-101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 }}
*{{cite journal | author=Ross MT, Grafham DV, Coffey AJ, ''et al.'' |title=The DNA sequence of the human X chromosome. |journal=Nature |volume=434 |issue= 7031 |pages= 325-37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440 }}
*{{cite journal  | author=Soubry A, van Hengel J, Parthoens E, ''et al.'' |title=Expression and nuclear location of the transcriptional repressor Kaiso is regulated by the tumor microenvironment. |journal=Cancer Res. |volume=65 |issue= 6 |pages= 2224-33 |year= 2005 |pmid= 15781635 |doi= 10.1158/0008-5472.CAN-04-2020 }}
*{{cite journal | author=Spring CM, Kelly KF, O'Kelly I, ''et al.'' |title=The catenin p120ctn inhibits Kaiso-mediated transcriptional repression of the beta-catenin/TCF target gene matrilysin. |journal=Exp. Cell Res. |volume=305 |issue= 2 |pages= 253-65 |year= 2005 |pmid= 15817151 |doi= 10.1016/j.yexcr.2005.01.007 }}
*{{cite journal | author=Arányi T, Faucheux BA, Khalfallah O, ''et al.'' |title=The tissue-specific methylation of the human tyrosine hydroxylase gene reveals new regulatory elements in the first exon. |journal=J. Neurochem. |volume=94 |issue= 1 |pages= 129-39 |year= 2005 |pmid= 15953356 |doi= 10.1111/j.1471-4159.2005.03173.x }}
*{{cite journal | author=Defossez PA, Kelly KF, Filion GJ, ''et al.'' |title=The human enhancer blocker CTC-binding factor interacts with the transcription factor Kaiso. |journal=J. Biol. Chem. |volume=280 |issue= 52 |pages= 43017-23 |year= 2006 |pmid= 16230345 |doi= 10.1074/jbc.M510802200 }}
}}
{{refend}}
{{refend}}


== External links ==
== External links ==
* {{MeshName|ZBTB33+protein,+human}}
* {{MeshName|ZBTB33+protein,+human}}
* {{FactorBook|ZBTB33}}
* {{UCSC genome browser|ZBTB33}}
* {{UCSC gene details|ZBTB33}}


{{NLM content}}
{{Transcription factors|g2}}


{{protein-stub}}
{{NLM content}}
{{Transcription factors}}
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}
 
{{gene-X-stub}}

Latest revision as of 01:04, 19 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Transcriptional regulator Kaiso is a protein that in humans is encoded by the ZBTB33 gene.[1] This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-α2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear import of this protein. Alternatively spliced transcript variants encoding the same protein have been identified.[2]

Interactions

ZBTB33 has been shown to interact with HDAC3,[3] Nuclear receptor co-repressor 1[3] and CTNND1.[4]

References

  1. ↑ "Entrez Gene: ZBTB33 zinc finger and BTB domain containing 33".
  2. ↑ "ZBTB33 zinc finger and BTB domain containing 33 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2016-03-22.
  3. ↑ 3.0 3.1 Yoon HG, Chan DW, Reynolds AB, Qin J, Wong J (Sep 2003). "N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso". Molecular Cell. 12 (3): 723–34. doi:10.1016/j.molcel.2003.08.008. PMID 14527417.
  4. ↑ Daniel JM, Reynolds AB (May 1999). "The catenin p120(ctn) interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor". Molecular and Cellular Biology. 19 (5): 3614–23. doi:10.1128/mcb.19.5.3614. PMC 84161. PMID 10207085.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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