Testicular receptor 2: Difference between revisions
Jump to navigation
Jump to search
m Robot: Automated text replacement (-{{reflist}} +{{reflist|2}}, -<references /> +{{reflist|2}}, -{{WikiDoc Cardiology Network Infobox}} +) |
m Bot: HTTP→HTTPS |
||
Line 1: | Line 1: | ||
{{Infobox_gene}} | |||
{{ | The '''testicular receptor 2''' ('''TR2''') also known as '''NR2C1''' (nuclear receptor subfamily 2, group C, member 1) is [[protein]] that in humans is encoded by the ''NR2C1'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NR2C1 nuclear receptor subfamily 2, group C, member 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7181| accessdate = }}</ref><ref name="pmid2597158">{{cite journal | vauthors = Chang C, Kokontis J, Acakpo-Satchivi L, Liao S, Takeda H, Chang Y | title = Molecular cloning of new human TR2 receptors: a class of steroid receptor with multiple ligand-binding domains | journal = Biochemical and Biophysical Research Communications | volume = 165 | issue = 2 | pages = 735–41 | date = Dec 1989 | pmid = 2597158 | doi = 10.1016/S0006-291X(89)80028-2 }}</ref> TR2 is a member of the [[nuclear receptor]] family of [[transcription factor]]s. | ||
| | |||
| | |||
| | |||
| | |||
| | |||
}} | |||
== Interactions == | |||
Testicular receptor 2 has been shown to [[Protein-protein_interaction|interact]] with: | |||
* [[Androgen receptor]],<ref name="pmid12949936">{{cite journal | vauthors = Mu X, Chang C | title = TR2 orphan receptor functions as negative modulator for androgen receptor in prostate cancer cells PC-3 | journal = The Prostate | volume = 57 | issue = 2 | pages = 129–33 | date = Oct 2003 | pmid = 12949936 | doi = 10.1002/pros.10282 }}</ref> | |||
* [[Estrogen receptor alpha]],<ref name="pmid12093804">{{cite journal | vauthors = Hu YC, Shyr CR, Che W, Mu XM, Kim E, Chang C | title = Suppression of estrogen receptor-mediated transcription and cell growth by interaction with TR2 orphan receptor | journal = The Journal of Biological Chemistry | volume = 277 | issue = 37 | pages = 33571–9 | date = Sep 2002 | pmid = 12093804 | doi = 10.1074/jbc.M203531200 }}</ref> | |||
* [[HDAC3]],<ref name="pmid14521922">{{cite journal | vauthors = Li G, Franco PJ, Wei LN | title = Identification of histone deacetylase-3 domains that interact with the orphan nuclear receptor TR2 | journal = Biochemical and Biophysical Research Communications | volume = 310 | issue = 2 | pages = 384–90 | date = Oct 2003 | pmid = 14521922 | doi = 10.1016/j.bbrc.2003.08.145 }}</ref><ref name="pmid12943985">{{cite journal | vauthors = Franco PJ, Li G, Wei LN | title = Interaction of nuclear receptor zinc finger DNA binding domains with histone deacetylase | journal = Molecular and Cellular Endocrinology | volume = 206 | issue = 1-2 | pages = 1–12 | date = Aug 2003 | pmid = 12943985 | doi = 10.1016/S0303-7207(03)00254-5 }}</ref><ref name="pmid11463856">{{cite journal | vauthors = Franco PJ, Farooqui M, Seto E, Wei LN | title = The orphan nuclear receptor TR2 interacts directly with both class I and class II histone deacetylases | journal = Molecular Endocrinology | volume = 15 | issue = 8 | pages = 1318–28 | date = Aug 2001 | pmid = 11463856 | doi = 10.1210/mend.15.8.0682 }}</ref> and | |||
* [[HDAC4]].<ref name=pmid12943985/><ref name=pmid11463856/> | |||
== See also == | |||
* [[Testicular receptor]] | |||
== | == References == | ||
{{reflist}} | |||
== Further reading == | |||
==Further reading== | |||
{{refbegin | 2}} | {{refbegin | 2}} | ||
* {{cite journal | vauthors = Chang C, Kokontis J | title = Identification of a new member of the steroid receptor super-family by cloning and sequence analysis | journal = Biochemical and Biophysical Research Communications | volume = 155 | issue = 2 | pages = 971–7 | date = Sep 1988 | pmid = 3421977 | doi = 10.1016/S0006-291X(88)80591-6 }} | |||
* {{cite journal | vauthors = Lin DL, Wu SQ, Chang C | title = The genomic structure and chromosomal location of the human TR2 orphan receptor, a member of the steroid receptor superfamily | journal = Endocrine | volume = 8 | issue = 2 | pages = 123–34 | date = Apr 1998 | pmid = 9704569 | doi = 10.1385/ENDO:8:2:123 }} | |||
*{{cite journal | * {{cite journal | vauthors = Lee CH, Chinpaisal C, Wei LN | title = A novel nuclear receptor heterodimerization pathway mediated by orphan receptors TR2 and TR4 | journal = The Journal of Biological Chemistry | volume = 273 | issue = 39 | pages = 25209–15 | date = Sep 1998 | pmid = 9737983 | doi = 10.1074/jbc.273.39.25209 }} | ||
* {{cite journal | vauthors = Lee CH, Chinpaisal C, Wei LN | title = Cloning and characterization of mouse RIP140, a corepressor for nuclear orphan receptor TR2 | journal = Molecular and Cellular Biology | volume = 18 | issue = 11 | pages = 6745–55 | date = Nov 1998 | pmid = 9774688 | pmc = 109258 | doi = 10.1128/mcb.18.11.6745}} | |||
*{{cite journal | * {{cite journal | vauthors = Yu Z, Lee CH, Chinpaisal C, Wei LN | title = A constitutive nuclear localization signal from the second zinc-finger of orphan nuclear receptor TR2 | journal = The Journal of Endocrinology | volume = 159 | issue = 1 | pages = 53–60 | date = Oct 1998 | pmid = 9795341 | doi = 10.1677/joe.0.1590053 }} | ||
*{{cite journal | * {{cite journal | vauthors = Franco PJ, Farooqui M, Seto E, Wei LN | title = The orphan nuclear receptor TR2 interacts directly with both class I and class II histone deacetylases | journal = Molecular Endocrinology | volume = 15 | issue = 8 | pages = 1318–28 | date = Aug 2001 | pmid = 11463856 | doi = 10.1210/mend.15.8.0682 }} | ||
*{{cite journal | * {{cite journal | vauthors = Tanabe O, Katsuoka F, Campbell AD, Song W, Yamamoto M, Tanimoto K, Engel JD | title = An embryonic/fetal beta-type globin gene repressor contains a nuclear receptor TR2/TR4 heterodimer | journal = The EMBO Journal | volume = 21 | issue = 13 | pages = 3434–42 | date = Jul 2002 | pmid = 12093744 | pmc = 126089 | doi = 10.1093/emboj/cdf340 }} | ||
*{{cite journal | * {{cite journal | vauthors = Hu YC, Shyr CR, Che W, Mu XM, Kim E, Chang C | title = Suppression of estrogen receptor-mediated transcription and cell growth by interaction with TR2 orphan receptor | journal = The Journal of Biological Chemistry | volume = 277 | issue = 37 | pages = 33571–9 | date = Sep 2002 | pmid = 12093804 | doi = 10.1074/jbc.M203531200 }} | ||
*{{cite journal | * {{cite journal | vauthors = Inui S, Lee YF, Chang E, Shyr CR, Chang C | title = Differential and bi-directional regulation between TR2/TR4 orphan nuclear receptors and a specific ligand mediated-peroxisome proliferator-activated receptor alpha in human HaCaT keratinocytes | journal = Journal of Dermatological Science | volume = 31 | issue = 1 | pages = 65–71 | date = Feb 2003 | pmid = 12615366 | doi = 10.1016/S0923-1811(02)00152-4 }} | ||
*{{cite journal | * {{cite journal | vauthors = Franco PJ, Li G, Wei LN | title = Interaction of nuclear receptor zinc finger DNA binding domains with histone deacetylase | journal = Molecular and Cellular Endocrinology | volume = 206 | issue = 1-2 | pages = 1–12 | date = Aug 2003 | pmid = 12943985 | doi = 10.1016/S0303-7207(03)00254-5 }} | ||
*{{cite journal | * {{cite journal | vauthors = Mu X, Chang C | title = TR2 orphan receptor functions as negative modulator for androgen receptor in prostate cancer cells PC-3 | journal = The Prostate | volume = 57 | issue = 2 | pages = 129–33 | date = Oct 2003 | pmid = 12949936 | doi = 10.1002/pros.10282 }} | ||
*{{cite journal | * {{cite journal | vauthors = Li G, Franco PJ, Wei LN | title = Identification of histone deacetylase-3 domains that interact with the orphan nuclear receptor TR2 | journal = Biochemical and Biophysical Research Communications | volume = 310 | issue = 2 | pages = 384–90 | date = Oct 2003 | pmid = 14521922 | doi = 10.1016/j.bbrc.2003.08.145 }} | ||
* {{cite journal | vauthors = Lin YL, Wang YH, Lee HJ | title = Transcriptional regulation of the human TR2 orphan receptor gene by nuclear factor 1-A | journal = Biochemical and Biophysical Research Communications | volume = 350 | issue = 2 | pages = 430–6 | date = Nov 2006 | pmid = 17010934 | doi = 10.1016/j.bbrc.2006.09.061 }} | |||
*{{cite journal | |||
*{{cite journal | |||
*{{cite journal | |||
*{{cite journal | |||
}} | |||
{{refend}} | {{refend}} | ||
{{ | {{gene-12-stub}} | ||
{{Transcription factors}} | {{Transcription factors|g2}} | ||
[[Category:Intracellular receptors]] | [[Category:Intracellular receptors]] | ||
[[Category:Transcription factors]] | [[Category:Transcription factors]] | ||
Latest revision as of 16:54, 15 September 2017
VALUE_ERROR (nil) | |||||||
---|---|---|---|---|---|---|---|
Identifiers | |||||||
Aliases | |||||||
External IDs | GeneCards: [1] | ||||||
Orthologs | |||||||
Species | Human | Mouse | |||||
Entrez |
|
| |||||
Ensembl |
|
| |||||
UniProt |
|
| |||||
RefSeq (mRNA) |
|
| |||||
RefSeq (protein) |
|
| |||||
Location (UCSC) | n/a | n/a | |||||
PubMed search | n/a | n/a | |||||
Wikidata | |||||||
|
The testicular receptor 2 (TR2) also known as NR2C1 (nuclear receptor subfamily 2, group C, member 1) is protein that in humans is encoded by the NR2C1 gene.[1][2] TR2 is a member of the nuclear receptor family of transcription factors.
Interactions
Testicular receptor 2 has been shown to interact with:
See also
References
- ↑ "Entrez Gene: NR2C1 nuclear receptor subfamily 2, group C, member 1".
- ↑ Chang C, Kokontis J, Acakpo-Satchivi L, Liao S, Takeda H, Chang Y (Dec 1989). "Molecular cloning of new human TR2 receptors: a class of steroid receptor with multiple ligand-binding domains". Biochemical and Biophysical Research Communications. 165 (2): 735–41. doi:10.1016/S0006-291X(89)80028-2. PMID 2597158.
- ↑ Mu X, Chang C (Oct 2003). "TR2 orphan receptor functions as negative modulator for androgen receptor in prostate cancer cells PC-3". The Prostate. 57 (2): 129–33. doi:10.1002/pros.10282. PMID 12949936.
- ↑ Hu YC, Shyr CR, Che W, Mu XM, Kim E, Chang C (Sep 2002). "Suppression of estrogen receptor-mediated transcription and cell growth by interaction with TR2 orphan receptor". The Journal of Biological Chemistry. 277 (37): 33571–9. doi:10.1074/jbc.M203531200. PMID 12093804.
- ↑ Li G, Franco PJ, Wei LN (Oct 2003). "Identification of histone deacetylase-3 domains that interact with the orphan nuclear receptor TR2". Biochemical and Biophysical Research Communications. 310 (2): 384–90. doi:10.1016/j.bbrc.2003.08.145. PMID 14521922.
- ↑ 6.0 6.1 Franco PJ, Li G, Wei LN (Aug 2003). "Interaction of nuclear receptor zinc finger DNA binding domains with histone deacetylase". Molecular and Cellular Endocrinology. 206 (1–2): 1–12. doi:10.1016/S0303-7207(03)00254-5. PMID 12943985.
- ↑ 7.0 7.1 Franco PJ, Farooqui M, Seto E, Wei LN (Aug 2001). "The orphan nuclear receptor TR2 interacts directly with both class I and class II histone deacetylases". Molecular Endocrinology. 15 (8): 1318–28. doi:10.1210/mend.15.8.0682. PMID 11463856.
Further reading
- Chang C, Kokontis J (Sep 1988). "Identification of a new member of the steroid receptor super-family by cloning and sequence analysis". Biochemical and Biophysical Research Communications. 155 (2): 971–7. doi:10.1016/S0006-291X(88)80591-6. PMID 3421977.
- Lin DL, Wu SQ, Chang C (Apr 1998). "The genomic structure and chromosomal location of the human TR2 orphan receptor, a member of the steroid receptor superfamily". Endocrine. 8 (2): 123–34. doi:10.1385/ENDO:8:2:123. PMID 9704569.
- Lee CH, Chinpaisal C, Wei LN (Sep 1998). "A novel nuclear receptor heterodimerization pathway mediated by orphan receptors TR2 and TR4". The Journal of Biological Chemistry. 273 (39): 25209–15. doi:10.1074/jbc.273.39.25209. PMID 9737983.
- Lee CH, Chinpaisal C, Wei LN (Nov 1998). "Cloning and characterization of mouse RIP140, a corepressor for nuclear orphan receptor TR2". Molecular and Cellular Biology. 18 (11): 6745–55. doi:10.1128/mcb.18.11.6745. PMC 109258. PMID 9774688.
- Yu Z, Lee CH, Chinpaisal C, Wei LN (Oct 1998). "A constitutive nuclear localization signal from the second zinc-finger of orphan nuclear receptor TR2". The Journal of Endocrinology. 159 (1): 53–60. doi:10.1677/joe.0.1590053. PMID 9795341.
- Franco PJ, Farooqui M, Seto E, Wei LN (Aug 2001). "The orphan nuclear receptor TR2 interacts directly with both class I and class II histone deacetylases". Molecular Endocrinology. 15 (8): 1318–28. doi:10.1210/mend.15.8.0682. PMID 11463856.
- Tanabe O, Katsuoka F, Campbell AD, Song W, Yamamoto M, Tanimoto K, Engel JD (Jul 2002). "An embryonic/fetal beta-type globin gene repressor contains a nuclear receptor TR2/TR4 heterodimer". The EMBO Journal. 21 (13): 3434–42. doi:10.1093/emboj/cdf340. PMC 126089. PMID 12093744.
- Hu YC, Shyr CR, Che W, Mu XM, Kim E, Chang C (Sep 2002). "Suppression of estrogen receptor-mediated transcription and cell growth by interaction with TR2 orphan receptor". The Journal of Biological Chemistry. 277 (37): 33571–9. doi:10.1074/jbc.M203531200. PMID 12093804.
- Inui S, Lee YF, Chang E, Shyr CR, Chang C (Feb 2003). "Differential and bi-directional regulation between TR2/TR4 orphan nuclear receptors and a specific ligand mediated-peroxisome proliferator-activated receptor alpha in human HaCaT keratinocytes". Journal of Dermatological Science. 31 (1): 65–71. doi:10.1016/S0923-1811(02)00152-4. PMID 12615366.
- Franco PJ, Li G, Wei LN (Aug 2003). "Interaction of nuclear receptor zinc finger DNA binding domains with histone deacetylase". Molecular and Cellular Endocrinology. 206 (1–2): 1–12. doi:10.1016/S0303-7207(03)00254-5. PMID 12943985.
- Mu X, Chang C (Oct 2003). "TR2 orphan receptor functions as negative modulator for androgen receptor in prostate cancer cells PC-3". The Prostate. 57 (2): 129–33. doi:10.1002/pros.10282. PMID 12949936.
- Li G, Franco PJ, Wei LN (Oct 2003). "Identification of histone deacetylase-3 domains that interact with the orphan nuclear receptor TR2". Biochemical and Biophysical Research Communications. 310 (2): 384–90. doi:10.1016/j.bbrc.2003.08.145. PMID 14521922.
- Lin YL, Wang YH, Lee HJ (Nov 2006). "Transcriptional regulation of the human TR2 orphan receptor gene by nuclear factor 1-A". Biochemical and Biophysical Research Communications. 350 (2): 430–6. doi:10.1016/j.bbrc.2006.09.061. PMID 17010934.
This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it. |