RUNX1T1: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{reflist}} +{{reflist|2}}, -<references /> +{{reflist|2}}, -{{WikiDoc Cardiology Network Infobox}} +))
 
m (Bot: HTTP→HTTPS)
 
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Protein CBFA2T1''' is a [[protein]] that in humans is encoded by the ''RUNX1T1'' [[gene]].<ref name="pmid1391946">{{cite journal | vauthors = Erickson P, Gao J, Chang KS, Look T, Whisenant E, Raimondi S, Lasher R, Trujillo J, Rowley J, Drabkin H | title = Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt | journal = Blood | volume = 80 | issue = 7 | pages = 1825–31 | date = October 1992 | pmid = 1391946 | pmc =  | doi =  }}</ref><ref name="pmid9790752">{{cite journal | vauthors = Calabi F, Cilli V | title = CBFA2T1, a gene rearranged in human leukemia, is a member of a multigene family | journal = Genomics | volume = 52 | issue = 3 | pages = 332–341 | date = Dec 1998 | pmid = 9790752 | pmc = | doi = 10.1006/geno.1998.5429 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=862| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_RUNX1T1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1wq6.
| PDB = {{PDB2|1wq6}}, {{PDB2|2dj8}}, {{PDB2|2h7b}}
| Name = Runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
| HGNCid = 1535
| Symbol = RUNX1T1
| AltSymbols =; AML1T1; CBFA2T1; CDR; ETO; MGC2796; MTG8; MTG8b; ZMYND2
| OMIM = 133435
| ECnumber = 
| Homologene = 3801
| MGIid = 104793
| GeneAtlas_image1 = PBB_GE_RUNX1T1_205529_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_RUNX1T1_205528_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_RUNX1T1_216831_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016564 |text = transcription repressor activity}} {{GNF_GO|id=GO:0042803 |text = protein homodimerization activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006091 |text = generation of precursor metabolites and energy}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0045444 |text = fat cell differentiation}} {{GNF_GO|id=GO:0051101 |text = regulation of DNA binding}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 862
    | Hs_Ensembl = ENSG00000079102
    | Hs_RefseqProtein = NP_004340
    | Hs_RefseqmRNA = NM_004349
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 8
    | Hs_GenLoc_start = 93040328
    | Hs_GenLoc_end = 93176619
    | Hs_Uniprot = Q06455
    | Mm_EntrezGene = 12395
    | Mm_Ensembl = ENSMUSG00000006586
    | Mm_RefseqmRNA = XM_975417
    | Mm_RefseqProtein = XP_980511
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 13670583
    | Mm_GenLoc_end = 13818712
    | Mm_Uniprot = Q61909
  }}
}}
'''Runt-related transcription factor 1; translocated to, 1 (cyclin D-related)''', also known as '''RUNX1T1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=862| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene is a putative zinc finger transcription factor and oncoprotein. In [[acute myeloid leukemia]], especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the [[RUNX1]] gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Several transcript variants encoding multiple isoforms have been found for this gene.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a putative zinc finger transcription factor and oncoprotein. In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Several transcript variants encoding multiple isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=862| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
RUNX1T1 has been shown to [[Protein-protein interaction|interact]] with:
==Further reading==
{{div col|colwidth=20em}}
{{refbegin | 2}}
* [[CBFA2T2]],<ref name = pmid16189514>{{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = October 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}</ref><ref name = pmid14703694>{{cite journal | vauthors = Lindberg SR, Olsson A, Persson AM, Olsson I | title = Interactions between the leukaemia-associated ETO homologues of nuclear repressor proteins | journal = Eur. J. Haematol. | volume = 71 | issue = 6 | pages = 439–47 | date = Dec 2003 | pmid = 14703694 | doi =  10.1046/j.0902-4441.2003.00166.x}}</ref><ref name = pmid12242670>{{cite journal | vauthors = Hoogeveen AT, Rossetti S, Stoyanova V, Schonkeren J, Fenaroli A, Schiaffonati L, van Unen L, Sacchi N | title = The transcriptional corepressor MTG16a contains a novel nucleolar targeting sequence deranged in t (16; 21)-positive myeloid malignancies | journal = Oncogene | volume = 21 | issue = 43 | pages = 6703–12 | date = September 2002 | pmid = 12242670 | doi = 10.1038/sj.onc.1205882 }}</ref>
{{PBB_Further_reading
* [[CBFA2T3]],<ref name = pmid14703694/><ref name = pmid12242670/>
| citations =  
* [[Calcitriol receptor]]<ref name = pmid12460926>{{cite journal | vauthors = Puccetti E, Obradovic D, Beissert T, Bianchini A, Washburn B, Chiaradonna F, Boehrer S, Hoelzer D, Ottmann OG, Pelicci PG, Nervi C, Ruthardt M | title = AML-associated translocation products block vitamin D(3)-induced differentiation by sequestering the vitamin D(3) receptor | journal = Cancer Res. | volume = 62 | issue = 23 | pages = 7050–8 | date = Dec 2002 | pmid = 12460926 | doi =  }}</ref>
*{{cite journal | author=Ferrara F, Del Vecchio L |title=Acute myeloid leukemia with t(8;21)/AML1/ETO: a distinct biological and clinical entity. |journal=Haematologica |volume=87 |issue= 3 |pages= 306-19 |year= 2002 |pmid= 11869944 |doi=  }}
* [[GFI1]],<ref name = pmid12874834>{{cite journal | vauthors = McGhee L, Bryan J, Elliott L, Grimes HL, Kazanjian A, Davis JN, Meyers S | title = Gfi-1 attaches to the nuclear matrix, associates with ETO (MTG8) and histone deacetylase proteins, and represses transcription using a TSA-sensitive mechanism | journal = J. Cell. Biochem. | volume = 89 | issue = 5 | pages = 1005–18 | date = August 2003 | pmid = 12874834 | doi = 10.1002/jcb.10548 }}</ref>
*{{cite journal  | author=Erickson P, Gao J, Chang KS, ''et al.'' |title=Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt. |journal=Blood |volume=80 |issue= 7 |pages= 1825-31 |year= 1992 |pmid= 1391946 |doi= }}
* [[Nuclear receptor co-repressor 1]],<ref name = pmid11533236>{{cite journal | vauthors = Amann JM, Nip J, Strom DK, Lutterbach B, Harada H, Lenny N, Downing JR, Meyers S, Hiebert SW | title = ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain | journal = Mol. Cell. Biol. | volume = 21 | issue = 19 | pages = 6470–83 | date = October 2001 | pmid = 11533236 | pmc = 99794 | doi =  10.1128/mcb.21.19.6470-6483.2001}}</ref><ref name = pmid11113190>{{cite journal | vauthors = Zhang J, Hug BA, Huang EY, Chen CW, Gelmetti V, Maccarana M, Minucci S, Pelicci PG, Lazar MA | title = Oligomerization of ETO is obligatory for corepressor interaction | journal = Mol. Cell. Biol. | volume = 21 | issue = 1 | pages = 156–63 | date = January 2001 | pmid = 11113190 | pmc = 88789 | doi = 10.1128/MCB.21.1.156-163.2001 }}</ref>
*{{cite journal | author=Nisson PE, Watkins PC, Sacchi N |title=Transcriptionally active chimeric gene derived from the fusion of the AML1 gene and a novel gene on chromosome 8 in t(8;21) leukemic cells. |journal=Cancer Genet. Cytogenet. |volume=63 |issue= 2 |pages= 81-8 |year= 1992 |pmid= 1423235 |doi=  }}
* [[Nuclear receptor co-repressor 2]],<ref name = pmid11113190/><ref name = pmid14982881>{{cite journal | vauthors = Takahashi S, McConnell MJ, Harigae H, Kaku M, Sasaki T, Melnick AM, Licht JD | title = The Flt3 internal tandem duplication mutant inhibits the function of transcriptional repressors by blocking interactions with SMRT | journal = Blood | volume = 103 | issue = 12 | pages = 4650–8 | date = June 2004 | pmid = 14982881 | doi = 10.1182/blood-2003-08-2759 }}</ref>
*{{cite journal | author=Era T, Asou N, Kunisada T, ''et al.'' |title=Identification of two transcripts of AML1/ETO-fused gene in t(8;21) leukemic cells and expression of wild-type ETO gene in hematopoietic cells. |journal=Genes Chromosomes Cancer |volume=13 |issue= 1 |pages= 25-33 |year= 1995 |pmid= 7541640 |doi= }}
* [[PRKAR2A]],<ref name = pmid11593431>{{cite journal | vauthors = Fukuyama T, Sueoka E, Sugio Y, Otsuka T, Niho Y, Akagi K, Kozu T | title = MTG8 proto-oncoprotein interacts with the regulatory subunit of type II cyclic AMP-dependent protein kinase in lymphocytes | journal = Oncogene | volume = 20 | issue = 43 | pages = 6225–32 | date = September 2001 | pmid = 11593431 | doi = 10.1038/sj.onc.1204794 }}</ref> and
*{{cite journal | author=Tighe JE, Calabi F |title=Alternative, out-of-frame runt/MTG8 transcripts are encoded by the derivative (8) chromosome in the t(8;21) of acute myeloid leukemia M2. |journal=Blood |volume=84 |issue= 7 |pages= 2115-21 |year= 1994 |pmid= 7919324 |doi=  }}
* [[Zinc finger and BTB domain-containing protein 16]].<ref name = pmid10688654>{{cite journal | vauthors = Melnick AM, Westendorf JJ, Polinger A, Carlile GW, Arai S, Ball HJ, Lutterbach B, Hiebert SW, Licht JD | title = The ETO protein disrupted in t(8;21)-associated acute myeloid leukemia is a corepressor for the promyelocytic leukemia zinc finger protein | journal = Mol. Cell. Biol. | volume = 20 | issue = 6 | pages = 2075–86 | date = March 2000 | pmid = 10688654 | pmc = 110824 | doi = 10.1128/mcb.20.6.2075-2086.2000}}</ref><ref name = pmid11090081>{{cite journal | vauthors = Melnick A, Carlile GW, McConnell MJ, Polinger A, Hiebert SW, Licht JD | title = AML-1/ETO fusion protein is a dominant negative inhibitor of transcriptional repression by the promyelocytic leukemia zinc finger protein | journal = Blood | volume = 96 | issue = 12 | pages = 3939–47 | date = Dec 2000 | pmid = 11090081 | doi = }}</ref>
*{{cite journal | author=Erickson PF, Robinson M, Owens G, Drabkin HA |title=The ETO portion of acute myeloid leukemia t(8;21) fusion transcript encodes a highly evolutionarily conserved, putative transcription factor. |journal=Cancer Res. |volume=54 |issue= 7 |pages= 1782-6 |year= 1994 |pmid= 8137293 |doi= }}
{{Div col end}}
*{{cite journal | author=Miyoshi H, Kozu T, Shimizu K, ''et al.'' |title=The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript. |journal=EMBO J. |volume=12 |issue= 7 |pages= 2715-21 |year= 1993 |pmid= 8334990 |doi=  }}
 
*{{cite journal | author=Kozu T, Miyoshi H, Shimizu K, ''et al.'' |title=Junctions of the AML1/MTG8(ETO) fusion are constant in t(8;21) acute myeloid leukemia detected by reverse transcription polymerase chain reaction. |journal=Blood |volume=82 |issue= 4 |pages= 1270-6 |year= 1993 |pmid= 8353289 |doi= }}
== References ==
*{{cite journal | author=Niwa-Kawakita M, Miyoshi H, Gotoh O, ''et al.'' |title=Cloning and gene mapping of the mouse homologue of the CBFA2T1 gene associated with human acute myeloid leukemia. |journal=Genomics |volume=29 |issue= 3 |pages= 755-9 |year= 1996 |pmid= 8575770 |doi= 10.1006/geno.1995.9941 }}
{{Reflist}}
*{{cite journal | author=Erickson PF, Dessev G, Lasher RS, ''et al.'' |title=ETO and AML1 phosphoproteins are expressed in CD34+ hematopoietic progenitors: implications for t(8;21) leukemogenesis and monitoring residual disease. |journal=Blood |volume=88 |issue= 5 |pages= 1813-23 |year= 1996 |pmid= 8781439 |doi= }}
{{Clear}}
*{{cite journal | author=Wolford JK, Bogardus C, Prochazka M |title=Polymorphism in the 3' untranslated region of MTG8 is associated with obesity in Pima Indian males. |journal=Biochem. Biophys. Res. Commun. |volume=246 |issue= 3 |pages= 624-6 |year= 1998 |pmid= 9618262 |doi= 10.1006/bbrc.1998.8683 }}
 
*{{cite journal | author=Sacchi N, Tamanini F, Willemsen R, ''et al.'' |title=Subcellular localization of the oncoprotein MTG8 (CDR/ETO) in neural cells. |journal=Oncogene |volume=16 |issue= 20 |pages= 2609-15 |year= 1998 |pmid= 9632137 |doi= 10.1038/sj.onc.1201824 }}
== Further reading ==
*{{cite journal  | author=Wolford JK, Prochazka M |title=Structure and expression of the human MTG8/ETO gene. |journal=Gene |volume=212 |issue= 1 |pages= 103-9 |year= 1998 |pmid= 9661669 |doi=  }}
{{Refbegin | 2}}
*{{cite journal | author=Calabi F, Cilli V |title=CBFA2T1, a gene rearranged in human leukemia, is a member of a multigene family. |journal=Genomics |volume=52 |issue= 3 |pages= 332-41 |year= 1998 |pmid= 9790752 |doi= 10.1006/geno.1998.5429 }}
* {{cite journal | vauthors = Ferrara F, Del Vecchio L | title = Acute myeloid leukemia with t(8;21)/AML1/ETO: a distinct biological and clinical entity | journal = Haematologica | volume = 87 | issue = 3 | pages = 306–19 | year = 2002 | pmid = 11869944 | doi =  }}
*{{cite journal | author=Komori A, Sueoka E, Fujiki H, ''et al.'' |title=Association of MTG8 (ETO/CDR), a leukemia-related protein, with serine/threonine protein kinases and heat shock protein HSP90 in human hematopoietic cell lines. |journal=Jpn. J. Cancer Res. |volume=90 |issue= 1 |pages= 60-8 |year= 1999 |pmid= 10076566 |doi= }}
* {{cite journal | vauthors = Nisson PE, Watkins PC, Sacchi N | title = Transcriptionally active chimeric gene derived from the fusion of the AML1 gene and a novel gene on chromosome 8 in t(8;21) leukemic cells | journal = Cancer Genet. Cytogenet. | volume = 63 | issue = 2 | pages = 81–88 | year = 1992 | pmid = 1423235 | doi = 10.1016/0165-4608(92)90384-K }}
*{{cite journal | author=Morohoshi F, Mitani S, Mitsuhashi N, ''et al.'' |title=Structure and expression pattern of a human MTG8/ETO family gene, MTGR1. |journal=Gene |volume=241 |issue= 2 |pages= 287-95 |year= 2000 |pmid= 10675041 |doi=  }}
* {{cite journal | vauthors = Era T, Asou N, Kunisada T, Yamasaki H, Asou H, Kamada N, Nishikawa S, Yamaguchi K, Takatsuki K | title = Identification of two transcripts of AML1/ETO-fused gene in t(8;21) leukemic cells and expression of wild-type ETO gene in hematopoietic cells | journal = Genes Chromosomes Cancer | volume = 13 | issue = 1 | pages = 25–33 | year = 1995 | pmid = 7541640 | doi = 10.1002/gcc.2870130105 }}
*{{cite journal | author=Melnick AM, Westendorf JJ, Polinger A, ''et al.'' |title=The ETO protein disrupted in t(8;21)-associated acute myeloid leukemia is a corepressor for the promyelocytic leukemia zinc finger protein. |journal=Mol. Cell. Biol. |volume=20 |issue= 6 |pages= 2075-86 |year= 2000 |pmid= 10688654 |doi=  }}
* {{cite journal | vauthors = Tighe JE, Calabi F | title = Alternative, out-of-frame runt/MTG8 transcripts are encoded by the derivative (8) chromosome in the t(8;21) of acute myeloid leukemia M2 | journal = Blood | volume = 84 | issue = 7 | pages = 2115–21 | year = 1994 | pmid = 7919324 | doi =  }}
*{{cite journal | author=Miyamoto T, Weissman IL, Akashi K |title=AML1/ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal translocation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 13 |pages= 7521-6 |year= 2000 |pmid= 10861016 |doi=  }}
* {{cite journal | vauthors = Erickson PF, Robinson M, Owens G, Drabkin HA | title = The ETO portion of acute myeloid leukemia t(8;21) fusion transcript encodes a highly evolutionarily conserved, putative transcription factor | journal = Cancer Res. | volume = 54 | issue = 7 | pages = 1782–6 | year = 1994 | pmid = 8137293 | doi =  }}
*{{cite journal | author=Odaka Y, Mally A, Elliott LT, Meyers S |title=Nuclear import and subnuclear localization of the proto-oncoprotein ETO (MTG8). |journal=Oncogene |volume=19 |issue= 32 |pages= 3584-97 |year= 2000 |pmid= 10951564 |doi= 10.1038/sj.onc.1203689 }}
* {{cite journal | vauthors = Miyoshi H, Kozu T, Shimizu K, Enomoto K, Maseki N, Kaneko Y, Kamada N, Ohki M | title = The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript | journal = EMBO J. | volume = 12 | issue = 7 | pages = 2715–21 | year = 1993 | pmid = 8334990 | pmc = 413521 | doi =  }}
*{{cite journal | author=Wood JD, Nucifora FC, Duan K, ''et al.'' |title=Atrophin-1, the dentato-rubral and pallido-luysian atrophy gene product, interacts with ETO/MTG8 in the nuclear matrix and represses transcription. |journal=J. Cell Biol. |volume=150 |issue= 5 |pages= 939-48 |year= 2000 |pmid= 10973986 |doi=  }}
* {{cite journal | vauthors = Kozu T, Miyoshi H, Shimizu K, Maseki N, Kaneko Y, Asou H, Kamada N, Ohki M | title = Junctions of the AML1/MTG8(ETO) fusion are constant in t(8;21) acute myeloid leukemia detected by reverse transcription polymerase chain reaction | journal = Blood | volume = 82 | issue = 4 | pages = 1270–6 | year = 1993 | pmid = 8353289 | doi = }}
}}
* {{cite journal | vauthors = Niwa-Kawakita M, Miyoshi H, Gotoh O, Matsushima Y, Nishimura M, Shisa H, Ohki M | title = Cloning and gene mapping of the mouse homologue of the CBFA2T1 gene associated with human acute myeloid leukemia | journal = Genomics | volume = 29 | issue = 3 | pages = 755–759 | year = 1996 | pmid = 8575770 | doi = 10.1006/geno.1995.9941 }}
{{refend}}
* {{cite journal | vauthors = Erickson PF, Dessev G, Lasher RS, Philips G, Robinson M, Drabkin HA | title = ETO and AML1 phosphoproteins are expressed in CD34+ hematopoietic progenitors: implications for t(8;21) leukemogenesis and monitoring residual disease | journal = Blood | volume = 88 | issue = 5 | pages = 1813–23 | year = 1996 | pmid = 8781439 | doi =  }}
* {{cite journal | vauthors = Wolford JK, Bogardus C, Prochazka M | title = Polymorphism in the 3' untranslated region of MTG8 is associated with obesity in Pima Indian males | journal = Biochem. Biophys. Res. Commun. | volume = 246 | issue = 3 | pages = 624–626 | year = 1998 | pmid = 9618262 | doi = 10.1006/bbrc.1998.8683 }}
* {{cite journal | vauthors = Sacchi N, Tamanini F, Willemsen R, Denis-Donini S, Campiglio S, Hoogeveen AT | title = Subcellular localization of the oncoprotein MTG8 (CDR/ETO) in neural cells | journal = Oncogene | volume = 16 | issue = 20 | pages = 2609–2615 | year = 1998 | pmid = 9632137 | doi = 10.1038/sj.onc.1201824 }}
* {{cite journal | vauthors = Wolford JK, Prochazka M | title = Structure and expression of the human MTG8/ETO gene | journal = Gene | volume = 212 | issue = 1 | pages = 103–109 | year = 1998 | pmid = 9661669 | doi = 10.1016/S0378-1119(98)00141-3 }}
* {{cite journal | vauthors = Komori A, Sueoka E, Fujiki H, Ishii M, Kozu T | title = Association of MTG8 (ETO/CDR), a leukemia-related protein, with serine/threonine protein kinases and heat shock protein HSP90 in human hematopoietic cell lines | journal = Jpn. J. Cancer Res. | volume = 90 | issue = 1 | pages = 60–8 | year = 1999 | pmid = 10076566 | doi = 10.1111/j.1349-7006.1999.tb00666.x }}
* {{cite journal | vauthors = Morohoshi F, Mitani S, Mitsuhashi N, Kitabayashi I, Takahashi E, Suzuki M, Munakata N, Ohki M | title = Structure and expression pattern of a human MTG8/ETO family gene, MTGR1 | journal = Gene | volume = 241 | issue = 2 | pages = 287–295 | year = 2000 | pmid = 10675041 | doi = 10.1016/S0378-1119(99)00481-3 }}
* {{cite journal | vauthors = Melnick AM, Westendorf JJ, Polinger A, Carlile GW, Arai S, Ball HJ, Lutterbach B, Hiebert SW, Licht JD | title = The ETO protein disrupted in t(8;21)-associated acute myeloid leukemia is a corepressor for the promyelocytic leukemia zinc finger protein | journal = Mol. Cell. Biol. | volume = 20 | issue = 6 | pages = 2075–2086 | year = 2000 | pmid = 10688654 | pmc = 110824 | doi = 10.1128/MCB.20.6.2075-2086.2000 }}
* {{cite journal | vauthors = Miyamoto T, Weissman IL, Akashi K | title = AML1/ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal translocation | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 97 | issue = 13 | pages = 7521–7526 | year = 2000 | pmid = 10861016 | pmc = 16578 | doi = 10.1073/pnas.97.13.7521 }}
* {{cite journal | vauthors = Odaka Y, Mally A, Elliott LT, Meyers S | title = Nuclear import and subnuclear localization of the proto-oncoprotein ETO (MTG8) | journal = Oncogene | volume = 19 | issue = 32 | pages = 3584–3597 | year = 2000 | pmid = 10951564 | doi = 10.1038/sj.onc.1203689 }}
* {{cite journal | vauthors = Wood JD, Nucifora FC, Duan K, Zhang C, Wang J, Kim Y, Schilling G, Sacchi N, Liu JM, Ross CA | title = Atrophin-1, the dentato-rubral and pallido-luysian atrophy gene product, interacts with ETO/MTG8 in the nuclear matrix and represses transcription | journal = J. Cell Biol. | volume = 150 | issue = 5 | pages = 939–948 | year = 2000 | pmid = 10973986 | pmc = 2175251 | doi = 10.1083/jcb.150.5.939 }}
{{Refend}}
 
{{PDB Gallery|geneid=862}}
{{Transcription factors|g4}}


{{protein-stub}}
{{Transcription factors}}
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}

Latest revision as of 09:34, 10 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Protein CBFA2T1 is a protein that in humans is encoded by the RUNX1T1 gene.[1][2][3]

Function

The protein encoded by this gene is a putative zinc finger transcription factor and oncoprotein. In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Several transcript variants encoding multiple isoforms have been found for this gene.[3]

Interactions

RUNX1T1 has been shown to interact with:

References

  1. ↑ Erickson P, Gao J, Chang KS, Look T, Whisenant E, Raimondi S, Lasher R, Trujillo J, Rowley J, Drabkin H (October 1992). "Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt". Blood. 80 (7): 1825–31. PMID 1391946.
  2. ↑ Calabi F, Cilli V (Dec 1998). "CBFA2T1, a gene rearranged in human leukemia, is a member of a multigene family". Genomics. 52 (3): 332–341. doi:10.1006/geno.1998.5429. PMID 9790752.
  3. ↑ 3.0 3.1 "Entrez Gene: RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)".
  4. ↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  5. ↑ 5.0 5.1 Lindberg SR, Olsson A, Persson AM, Olsson I (Dec 2003). "Interactions between the leukaemia-associated ETO homologues of nuclear repressor proteins". Eur. J. Haematol. 71 (6): 439–47. doi:10.1046/j.0902-4441.2003.00166.x. PMID 14703694.
  6. ↑ 6.0 6.1 Hoogeveen AT, Rossetti S, Stoyanova V, Schonkeren J, Fenaroli A, Schiaffonati L, van Unen L, Sacchi N (September 2002). "The transcriptional corepressor MTG16a contains a novel nucleolar targeting sequence deranged in t (16; 21)-positive myeloid malignancies". Oncogene. 21 (43): 6703–12. doi:10.1038/sj.onc.1205882. PMID 12242670.
  7. ↑ Puccetti E, Obradovic D, Beissert T, Bianchini A, Washburn B, Chiaradonna F, Boehrer S, Hoelzer D, Ottmann OG, Pelicci PG, Nervi C, Ruthardt M (Dec 2002). "AML-associated translocation products block vitamin D(3)-induced differentiation by sequestering the vitamin D(3) receptor". Cancer Res. 62 (23): 7050–8. PMID 12460926.
  8. ↑ McGhee L, Bryan J, Elliott L, Grimes HL, Kazanjian A, Davis JN, Meyers S (August 2003). "Gfi-1 attaches to the nuclear matrix, associates with ETO (MTG8) and histone deacetylase proteins, and represses transcription using a TSA-sensitive mechanism". J. Cell. Biochem. 89 (5): 1005–18. doi:10.1002/jcb.10548. PMID 12874834.
  9. ↑ Amann JM, Nip J, Strom DK, Lutterbach B, Harada H, Lenny N, Downing JR, Meyers S, Hiebert SW (October 2001). "ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain". Mol. Cell. Biol. 21 (19): 6470–83. doi:10.1128/mcb.21.19.6470-6483.2001. PMC 99794. PMID 11533236.
  10. ↑ 10.0 10.1 Zhang J, Hug BA, Huang EY, Chen CW, Gelmetti V, Maccarana M, Minucci S, Pelicci PG, Lazar MA (January 2001). "Oligomerization of ETO is obligatory for corepressor interaction". Mol. Cell. Biol. 21 (1): 156–63. doi:10.1128/MCB.21.1.156-163.2001. PMC 88789. PMID 11113190.
  11. ↑ Takahashi S, McConnell MJ, Harigae H, Kaku M, Sasaki T, Melnick AM, Licht JD (June 2004). "The Flt3 internal tandem duplication mutant inhibits the function of transcriptional repressors by blocking interactions with SMRT". Blood. 103 (12): 4650–8. doi:10.1182/blood-2003-08-2759. PMID 14982881.
  12. ↑ Fukuyama T, Sueoka E, Sugio Y, Otsuka T, Niho Y, Akagi K, Kozu T (September 2001). "MTG8 proto-oncoprotein interacts with the regulatory subunit of type II cyclic AMP-dependent protein kinase in lymphocytes". Oncogene. 20 (43): 6225–32. doi:10.1038/sj.onc.1204794. PMID 11593431.
  13. ↑ Melnick AM, Westendorf JJ, Polinger A, Carlile GW, Arai S, Ball HJ, Lutterbach B, Hiebert SW, Licht JD (March 2000). "The ETO protein disrupted in t(8;21)-associated acute myeloid leukemia is a corepressor for the promyelocytic leukemia zinc finger protein". Mol. Cell. Biol. 20 (6): 2075–86. doi:10.1128/mcb.20.6.2075-2086.2000. PMC 110824. PMID 10688654.
  14. ↑ Melnick A, Carlile GW, McConnell MJ, Polinger A, Hiebert SW, Licht JD (Dec 2000). "AML-1/ETO fusion protein is a dominant negative inhibitor of transcriptional repression by the promyelocytic leukemia zinc finger protein". Blood. 96 (12): 3939–47. PMID 11090081.

Further reading

Retrieved from "https://www.wikidoc.org/index.php?title=RUNX1T1&oldid=1422174"