CREB1

CAMP responsive element binding protein 1
File:PBB Protein CREB1 image.jpg PDB rendering based on 1dh3.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1dh3​
Identifiers
Symbols	CREB1 ; CREB; MGC9284
External IDs	Template:OMIM5 Template:MGI HomoloGene: 3223
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

CAMP responsive element binding protein 1, also known as CREB1, is a human protein and gene. This protein binds the cAMP response element, a DNA nucleotide sequence present in many viral and cellular promoters. The binding of CREB1 stimulates transcription.

This gene encodes a CREB transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in two transcript variants encoding different isoforms.

See also

• CREB

Further reading

• Don J, Stelzer G (2003). "The expanding family of CREB/CREM transcription factors that are involved with spermatogenesis". Mol. Cell. Endocrinol. 187 (1–2): 115–24. PMID 11988318.
• Pandey SC (2005). "The gene transcription factor cyclic AMP-responsive element binding protein: role in positive and negative affective states of alcohol addiction". Pharmacol. Ther. 104 (1): 47–58. doi:10.1016/j.pharmthera.2004.08.002. PMID 15500908.
• Wu H, Zhou Y, Xiong ZQ (2007). "Transducer of regulated CREB and late phase long-term synaptic potentiation". FEBS J. 274 (13): 3218–23. doi:10.1111/j.1742-4658.2007.05891.x. PMID 17565597.CS1 maint: Multiple names: authors list (link)
• Kitagawa K (2007). "CREB and cAMP response element-mediated gene expression in the ischemic brain". FEBS J. 274 (13): 3210–7. doi:10.1111/j.1742-4658.2007.05890.x. PMID 17565598.
• Takemori H, Kajimura J, Okamoto M (2007). "TORC-SIK cascade regulates CREB activity through the basic leucine zipper domain". FEBS J. 274 (13): 3202–9. doi:10.1111/j.1742-4658.2007.05889.x. PMID 17565599.CS1 maint: Multiple names: authors list (link)
• Siu YT, Jin DY (2007). "CREB--a real culprit in oncogenesis". FEBS J. 274 (13): 3224–32. doi:10.1111/j.1742-4658.2007.05884.x. PMID 17565603.

External links

• CREB1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.